Wednesday, 23 June 2021 | 22:42 WIB

Compounds in Grapes Can Help Fight Colon Cancer Cells

Compounds in Grapes Can Help Fight Colon Cancer Cells (pixabay)

JAKARTA, NETRALNEWS.COM - You should start eating grapes every day, as recent research results reveal that the compounds found in the skins and seeds of grapes can kill colon cancer stem cells.

"The compound named resveratrol, found in the skin and seeds of grapes, helps prevent colon cancer. A combination of resveratrol extract and grape seed extract is very effective in killing colon cancer cells," said researcher Jairam K.P. Vanamala from Penn State Hershey Cancer Institute, as quoted from India Times.

The researchers suggested that the findings could pave the way for clinical testing of compounds in human colon cancer, which is the second most common cancer in women and the third in men.

If successful, the compound can then be used in pills to help prevent colon cancer and reduce the recurrence of disease in colon cancer patients.

Vanamala notes that according to cancer stem cell theory, cancerous tumors are driven by cancer stem cells. Cancer stem cells are capable of self-regeneration, cell differentiation and maintaining characteristics such as stem cells even after invasion and metastasis.

When taken separately in low doses, resveratrol extract and grape seed extract are ineffective against cancer stem cell suppression. However, the results are different if the two extracts combined together, according to the researchers.

"It also connects well with a structured plant-based diet so that people get different types of plants, from different parts of the plant and the color of different plants," Vanamala said.

For animal studies, they separated 52 mice with colon cancer tumors into three groups, including the control group and the group fed the wine or sulindac compounds, anti-inflammatory drugs, selected because of previous studies showing that it significantly reduced the number of tumors in human.

The incidence of the tumor was suppressed in mice who consumed the wine compound alone by 50 percent, similar to the group rate consuming the food with sulindac.

The study is published in the journal BMC Complementary and Alternative Medicine.